Human leukocyte antigen-B-associated transcript 3 (BAT3) is another NKp30 ligand that was shown to upregulate surface expression on melanoma cells upon the activation of the pattern recognition receptor, retinoic acid-inducible gene I (RIG-I), and its upregulation led to potent antitumor activity in melanoma mice models [30]. This evidence concerns the gene RIGI and melanoma.