Metabolism disorders caused by insufficient exercise or unbalanced nutrition can induce obesity, diabetes [12], lipogenic genes [sterol regulatory element-binding protein 1 (SREBP-1), liver X receptors (LXR), ATP-citrate lyase (ACL), and fatty acid synthase (FAS)] defects [13], weakness of antioxidant status and inflammation [14]. Here, ACLY is linked to obesity due to melanocortin 4 receptor deficiency.