This result is consistent with the previous report that minocycline attenuates HIF-1α expression through the Akt/mTOR/p70S6K/4E-BP1 pathway in human ovarian carcinoma cell lines (A2780, OVCAR-3 and SKOV-3) and mice harboring OVCAR-3 xenografts [51]. This evidence concerns the gene EIF4EBP1 and ovarian carcinoma.