PRKAR1A and ovarian carcinoma: To evaluate the cytotoxic effects of TSE1 and cisplatin on human ovarian cancer cell lines OVCAR-3 and A2780/CP70, as well as human normal epithelial ovarian cell line IOSE-364, cell viability was determined using the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethonyphenol)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay.