Besides anti-VEGF siRNA, experiments were performed with siRNA against key proteins in cancer, such as polo-like kinase 1 (serine-threonine kinase involved in the cell cycle) [187], aurora kinase A (serine-threonine kinase important for mitotic spindle formation) [188], induced myeloid leukemia cell differentiation protein (anti-apoptotic protein) [189] or survivin (a member of the family of inhibitors of apoptosis) [190]. This evidence concerns the gene VEGFA and cancer.