SOX2 and malignant colon neoplasm: This ability of oncogenic KRAS was demonstrated in mutant KRAS-transfected SW48 human colon cancer cells as well, where the induction of an ESC-like program was indicated by upregulation of factors required for reprogramming and ESC and colon cancer maintenance, e.g., SOX2, FGFR1, LCK, validated at both the mRNA and protein levels.