This ability of oncogenic KRAS was demonstrated in mutant KRAS-transfected SW48 human colon cancer cells as well, where the induction of an ESC-like program was indicated by upregulation of factors required for reprogramming and ESC and colon cancer maintenance, e.g., SOX2, FGFR1, LCK, validated at both the mRNA and protein levels. This evidence concerns the gene FGFR1 and malignant colon neoplasm.