This sequence of post-replication events on Chromosome 11 led to loss of 50 Mb of the telomere end of 11q in a lung cancer and loss of 53 Mb of the same chromosome arm in an esophageal adenocarcinoma, combined in both cases with amplification of the CCND1 oncogene encoding cyclin D [141]. Here, CCND1 is linked to lung carcinoma.