CCND1 and esophageal adenocarcinoma: This sequence of post-replication events on Chromosome 11 led to loss of 50 Mb of the telomere end of 11q in a lung cancer and loss of 53 Mb of the same chromosome arm in an esophageal adenocarcinoma, combined in both cases with amplification of the CCND1 oncogene encoding cyclin D [141].