CYP11B1 and neoplasm: The population of these hybrid tumor cells was small (CYP11B1+/CYP11B2+, mean 2.1%; CYP17A+/CYP11B2, mean 0.6%; CYP17A+/CYP11B1+/CYP11B2+, mean 0.14%), but the presence of the hybrid tumor cells could be evidence of deviated functional differentiation from the adrenal cortex, which has never been detected in the non-neoplastic/hyperplastic nodules [90].