To reveal whether ERK signaling is required for basal and rhTGFβ1-induced expression of aTGFβ1 in pancreatic cancer cells, we measured its expression by qPCR and ELISA in Panc1 cells that have been treated, or not, with rhTGFβ1 in the presence or absence of U0126, a selective MEK1/2 inhibitor [31]. This evidence concerns the gene MAP2K1 and familial pancreatic carcinoma.