We recently employed two human cancer cell lines with high autocrine TGFβ1 (aTGFβ1) production, namely Panc1, a PDAC-derived line with a quasi-mesenchymal signature, and MDA-MB-231, a TNBC-derived line of the basal-like subtype, to elucidate the underlying signaling pathways. This evidence concerns the gene TGFB1 and cancer.