In addition, MM cells promote the survival of MDSCs through Mcl-1 upregulation [95], secretion of IL-6, which drives MDSCs expansion by the activation of several molecular cascades such as PI3K/Akt or JAK/STAT3 [96,97], and through the accumulation of high levels of ADO by the conversion of NAD+ [23,98]. This evidence concerns the gene STAT3 and Miyoshi myopathy.