CD8A and Miyoshi myopathy: Additionally, an impaired response against viral antigens in MM patients has been observed [17], which may be associated to the increased expression of suppressor of cytokine signaling 1 (SOCS1) by T CD8+ subset, which, in turn, inhibits IL-2, IL-6 and IFN-γ production in these same cells, attenuating Th1 and cytotoxic T lymphocytes (CTL)-mediated responses [18].