Regarding effects on the PD-1/PD-L1 axis, the HDAC6 selective inhibitor ACY-241 significantly decreases PD-L1 expression on pDCs, which in turn attenuates PD-L1/PD-1-mediated NK suppression and enhances NK cell-mediated MM cell cytotoxicity [177]. This evidence concerns the gene CD274 and Miyoshi myopathy.