SCN9A and cancer: In particular, the GSE34053 dataset analyzed cancer-associated fibroblasts (CAF, tumor stromal cells) and CD133+ cells (tumor epithelial cells) [39]; while CD133+ cells expressed higher levels of KCNAB2 and KCNMB4, CAF cells (stroma) overexpressed SCN9A and KCNJ8 subunit channels (Table S1).