Moreover, significant associations were found between the presence of aCL IgG and acute ischemic encephalopathy in secondary APS, aCL IgM and epilepsy in secondary APS, aCL IgM and migraine in primary APS, β2-GPI IgG and chorea in secondary APS and β2-GPI IgM and transient ischemic attack and epilepsy in primary APS. This evidence concerns the gene CD40LG and autoimmune polyendocrinopathy.