For example, nivaldipine (a dyhidropyridine calcium channel blocker) was reported to improve the cognitive function of AD mice [64], while isradipine, a class of dihydropyridines that block Cav1.2 subtype, was reported to prevent memory loss by targeting the expression of L-type calcium channels (LTCC) in the CA1 region of the hippocampus in a mouse model of AD [65]. This evidence concerns the gene CACNA1C and Alzheimer disease.