The expression of the three proteins was also evaluated in whole tissue slides using IHC and significantly decreased staining intensities of QSOX1 and EDIL3 were observed in malignant tissue compared to patient matched normal tissue (Figure S6), and THBS1 again did not display differential protein expression between colon and CRC similar to patients 1–3. The gene discussed is EDIL3; the disease is colorectal carcinoma.