ACTN4 and neoplasm: These proteins (THBS1, FBLN1, EDIL3, QSOX1, ACTN4, MMP3) also displayed differential mRNA expression in CRC compared to healthy intestine in the CRC TCGA dataset [41], and are implicated in tumour growth [54,62,63,64,65,66,67,68,69,70] and metastasis regulation [55,63,65,66,67,71,72,73,74,75,76,77].