In healthy controls, rs3757385 (OR = 0.63, 95% CI: 0.46–0.85, pdominant = 0.002) and rs3807135 (OR = 0.67, 95% CI: 0.49–0.92, pcodominant 1 = 0.013) were associated with a low risk of hypoalphalipoproteinemia, rs3807134 with elevated non-HDL-cholesterol (OR = 1.78, 95% CI: 1.12–2.82, pheterozygote = 0.015), rs6968563 with elevated apolipoprotein B (OR = 2.04, 95% CI: 1.07–3.88, pheterozygote = 0.030), rs3807134 with a high risk of hyperuricemia (OR = 2.07, 95% CI: 1.24–3.43, pcodominant 1 = 0.005), and rs3778754 with elevated levels of TNF-α (OR = 1.51, 95% CI: 1.08–2.11, precessive = 0.017). The gene discussed is APOB; the disease is hypoalphalipoproteinemia.