MTDH and endometrial cancer: MTDH is generally localized in the nucleus and cytoplasm as well as at the plasma membrane and is functionally associated with several oncogenic signaling pathways, such as PI3K/AKT pathway, and transcription factors, such as nuclear factor NF-κB. Many studies show that MTDH is overexpressed in all solid tumors, including breast, prostate, gastric, renal, colorectal, ovarian, and endometrial cancers [7,8,9].