However, the elevated progression of CaP+CaOx (mixed) crystal formation in the KOT group showed the associated increase in urine CaP and the absence of TRPC3 provide evidence of the possible protective role of TRPC3 in calcium crystal formation possibly through its action in regulating the PT Ca2+ influx and preventing nephrocalcinosis. Here, TRPC3 is linked to nephrocalcinosis.