CSF1R and Leukoencephalopathy: Neuropathologically, CSF1R-related leukoencephalopathy resulted in patchy white matter degeneration, featuring atrophy and confluent bilateral white matter hyperintensities, accompanied by loss of myelin and axons, presence of neuroaxonal spheroids and lipid-laden and pigmented macrophages [208,212,213] that were observed 6 years prior to symptoms onset [208].