The risk variants that were the most frequent items were INTS8-rs78727559 (37 rules), TNIP3-rs17051321 (36 rules), HLA-DRB1*15:01 (25 rules), SLC30A7-rs56678847 (25 rules), and BCL10-rs3548693 (24 rules), suggesting these variants are probable genetic hubs in higher order genetic relationships contributing to MS risk. This evidence concerns the gene INTS8 and myeloid sarcoma.