These complex genetic patterns had strong associations with MS; i.e., HLA-DRB1*15:01-SLC30A7-rs56678847-AC093277.1-rs6880809 conferred 20.2-fold (95% CI: 8.5, 37.5; p = 4 × 10−9) increased MS risk. The gene discussed is HLA-DRB1; the disease is myeloid sarcoma.