The core components of the canonical Hippo pathway are two kinase complexes: the first is the sterile 20-like kinase (MST1/2) and the second involves the large tumor suppressors LATS1 and LATS2 (LATS1/2), the adaptor Salvador homolog 1 (SAV1), and the MOB kinase activator (MOB1A-B). This evidence concerns the gene LATS1 and neoplasm.