In zebrafish, KRASG12V overexpression under the neural promoters krt5 and gfap (specific for neurons, glial cells and astrocytes) led to malignant tumors in the cranial cavity and parenchymal brain tumors respectively, highlighting that different tumor initiating cells may well determine the tumor type and demonstrating that tumorigenesis is driven by the activation of the canonical Ras and mTOR pathways [123]. This evidence concerns the gene MTOR and brain neoplasm.