For instance, phosphatase and tensin homolog (PTEN) deficiency in glioma drives macrophage infiltration via up-regulation of lysyl oxidase (LOX) [35] and in mesenchymal GBMs neurofibromin 1 (NF1) deficiency results in increased GAM infiltration compared with proneural or classical subtypes [18,36,37]. This evidence concerns the gene NF1 and central nervous system cancer.