PTEN and central nervous system cancer: For instance, phosphatase and tensin homolog (PTEN) deficiency in glioma drives macrophage infiltration via up-regulation of lysyl oxidase (LOX) [35] and in mesenchymal GBMs neurofibromin 1 (NF1) deficiency results in increased GAM infiltration compared with proneural or classical subtypes [18,36,37].