Aerobic glycolysis, which favors the deadly progression of GBM [79] (Figure 2), is controlled by glucose transporters, GLUT1-4 and key glycolytic enzymes such as these: HK1-3, PFK1, GAPDH, PKM2 and LDHA; they are also influenced by several other cellular pathways and regulatory proteins, including the following: PI3K/AKT, LKB1/AMPK, HIF-1/2, p53, EGFR, PDGFR and c-MYC, among others. The gene discussed is TP53; the disease is glioblastoma.