IDH mutation occurs early in this process and stands out as the main biomarker used in the 2016 CNS WHO [3] to identify and classify GBM into the following types: (1) Glioblastoma IDH-wildtype (about 90% of cases): primary or de novo GBM that predominates in patients of over 55 years of age. The gene discussed is IDH2; the disease is glioblastoma.