EPHA4 and glioblastoma: As an example of this, experiments knocking down Ephrin-B3 ortholog and co-silencing EphA4 in zebrafish allowed impairments to be found in the formation of intersegmental vessels (ISVs) associated with EphA4-related apoptosis and angiogenesis, thus suggesting EphA4-induced cell death as an opportunity to slow GBM growth [127].