The animal study conducted by Cardoso et al. showed that the relationship between magnesium and the development of depression and depressive disorders may be associated with the influence of this bioelement on the dopaminergic, noradrenergic, and serotonergic systems through the 5-HT1A and 5-HT2A receptors [8]. The gene discussed is HTR1A; the disease is depressive symptom measurement.