The most prominent targets of these miRs are phosphatase and tensin homolog (PTEN), cyclin dependent kinase inhibitor 1A (CDKN1A), MDM2 proto-oncogene (MDM2), superoxide dismutase 2 (SOD2), high mobility group box 1 (HMGB1), insulin like growth factor 1 receptor (IGF1R), WEE1 G2 checkpoint kinase (WEE1), forkhead box K1 (FOXK1), and thioredoxin interacting protein (TXNIP), which play a crucial role in ovarian cancer progression. The gene discussed is HMGB1; the disease is ovarian cancer.