WFDC2 and ovarian carcinoma: Current diagnostic methods for the detection and monitoring of ovarian cancer include pelvic examination, transvaginal ultrasound, and measurement of the serum biomarker carbohydrate antigen 125 (CA125) [22], human epididymis protein 4 (HE4) [23] Wnt/beta-catenin [24], and p53 [25]; these methods have certainly improved outcomes, but have limitations and lack adequate sensitivity.