Nevertheless, the increasing knowledge of the genetic landscape of AML has shed light on the complex gene interplay affecting prognosis in AML and some disease categories (e.g., RUNX1-RUNX1T1 and NPM1 mutated AML) have resulted to be more complex than expected with a final outcome that may eventually be not as favorable as expected [7]. This evidence concerns the gene NPM1 and acute myeloid leukemia.