FLG and neoplasm: There are, however, significant differences between PTMmut and overall mutations, with e.g., hornerin (HRNR, a paralog of FLG) being a top-10 PTMmut gene in 14/31 tumor types and versican (VCAN), collagen III (COL3A1) and XIV (COL14A1) all mutated in 9/31 tumor types.