BTG3 and systemic lupus erythematosus: The diagnosis of anti-TNF-α-induced lupus is made by the temporal relation between the symptoms and start of anti-TNF-α therapy and resolution after stop, the presence of autoantibodies (positive ANA or anti-dsDNA), and at least 1 additional sign such as joint pain, fever, fatigue, serositis, or lupus-like skin lesions.