In vitro investigations showed that 4E1RCat also halted the decrease in interleukin-1β production, myeloperoxidase levels, and neutrophil recruitment in murine Aspergillus fumigatus keratitis by means of inhibiting eIF4E/4E-BP1 binding, as well as stopping the increase in fungal load and apoptosis [30]. This evidence concerns the gene EIF4E and keratitis.