EphB6 depletion is accompanied by reduced TFEB-dependent genes transcription in indolent breast cancer cells from lungs and lung-organotypic system (Figure 4C and Figure 5A) and decreased cytoplasmic area with Lysotracker-positive organelles (Figure 5C and Figure S3B) in mouse and human models of DDCCs. Here, EPHB6 is linked to breast carcinoma.