Although an improvement of haematocrit, albumin and ESR values while on a strict SCD was reported and this appeared stable after liberalization of the diet, both patients on the SCD ‘simple ‘(diet alone, antibiotics or 5-ASA) or SCD with immunomodulators (corticosteroids and/or stable thiopurine dosing) were included, raising the question if these positive results would have been obtained to the same extent when using a control [49]. This evidence concerns the gene ALB and Schnyder corneal dystrophy.