HDAC2 and neurodegenerative disease: Given that epigenetic dysregulation [14,15], mitochondrial dysfunction [16,17,18], and synaptic dysfunction [19] are all implicated in multiple neurodevelopmental and neurodegenerative diseases, we investigated whether modulation of HDAC2 expression would impact neuronal maturation, mitochondrial dynamics and synaptic gene expression in neuronal cells derived from hiPSCs (hiPSC-Ns).