The present study showed that metastatic prostate carcinoma cells (LNCaP, PC-3, and DU145) have higher MALT1 expression compared to non-metastatic cells (PZ-HPV-7 and CA-HPV-10), and MALT1 is abundant in advanced prostate cancerous tissues, suggesting that MALT1 could be an oncogene in the human prostate. This evidence concerns the gene MALT1 and prostate carcinoma.