The presence of novel positive feedback loop between MALT1 and NF-κB in prostate carcinoma cells indicates that MALT1 is a NF-κB-induced oncogene and the induction of NF-κB activation by MALT1 enhances cell proliferation, invasion, and tumor growth in the human prostate carcinoma cells in vitro and in vivo. The gene discussed is NFKB1; the disease is prostate carcinoma.