Additionally, the anti-inflammatory cytokine IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines, such as IFN-γ, IL-2, IL-3, and TNFα released by macrophages and Th1 cells, while low levels of IL-10 have been reported in patients with T2DM and metabolic syndrome [45]. This evidence concerns the gene IL10 and type 2 diabetes mellitus.