MDS predisposition syndromes may be associated with pancytopenia (telomeropathies, GATA2 related disorders, Shwachman-Diamond syndrome and SAMD9/SAMD9L related disorders), red cell aplasia (Diamond-Blackfan anemia), thrombocytopenia (RUNX1, ANKRD26 and ETV6 related disorders) and neutropenia (severe congenital neutropenia), which may present not only in children, but also in adults. The gene discussed is SAMD9; the disease is Pancytopenia.