MDS predisposition syndromes may be associated with pancytopenia (telomeropathies, GATA2 related disorders, Shwachman-Diamond syndrome and SAMD9/SAMD9L related disorders), red cell aplasia (Diamond-Blackfan anemia), thrombocytopenia (RUNX1, ANKRD26 and ETV6 related disorders) and neutropenia (severe congenital neutropenia), which may present not only in children, but also in adults. This evidence concerns the gene ETV6 and Thrombocytopenia.