That study did not find evidence for an association of the MTHFR(677)C>T polymorphism with altered placental DNA methylation using both genome-wide and site-specific approaches, but described a tendency for increased MTHFR(677)TT genotype in placentas from pregnancies complicated by pathologies such as preeclampsia and intrauterine growth restriction [45]. The gene discussed is MTHFR; the disease is preeclampsia.