It has been proposed that SNPs in the IL1β, IL1RN, FcγRIIIb, VDR, and TLR4 genes may underlie susceptibility to more destructive forms of periodontitis, while polymorphisms in the IL1B, IL1RN, IL6, IL10, VDR, CD14, TLR4, and MMP1 genes might be responsible for general susceptibility to chronic periodontitis [31]. The gene discussed is IL1RN; the disease is periodontitis.