This dual role of inflammasome is consistent with studies performed on other diseases such as cancer and Alzheimer’s disease, in which despite the fact that the inflammasome is directly involved in its pathogenesis, there are also reasons to speculate on whether a moderate degree of its activation could be beneficial, thus being NLRP3 inflammasome a double-edged sword [29,35,36,37,38]. This evidence concerns the gene NLRP3 and early-onset autosomal dominant Alzheimer disease.