MSTN and Duchenne muscular dystrophy: Later, the antibody PF-06252616 (domagrozumab, Pfizer), which neutralizes myostatin by binding to the mature myostatin dimer, increased lean body mass (LBM) and muscle volume by 5 and 4% in healthy subjects [155] but was unable to show an effect in DMD patients, and the phase II trial was terminated prematurely [156].