ATM and cyst: To further verify the effect of ATM inhibition on in vitro cyst growth and also to select candidates for in vivo testing, we next evaluated the efficacy of two orally bioavailable analogues: (i) AZD1390 (IC50, 0.78 nM, >10,000-fold selectivity for ATM) [29], and (ii) AZD0156 (IC50 0.58 nM, >1000-fold selectivity for ATM) [30].