They are made of three components: (i) a miR-16-based microRNA mimicking a double-stranded, 23-base pair, synthetic RNA molecule; (ii) biologically engineered drug delivery vehicle EnGeneIC Dream Vectors (EDVs), which are nonliving bacterial minicells (nanoparticles) that function as leak resistant micro-reservoir carriers that allow for efficient packaging of a range of different drugs, proteins, or nucleic acids; and (iii) targeting specificity, wherein the EDVs are targeted to EGFR-expressing cancer cells with an anti-EGFR bispecific antibody. The gene discussed is EGFR; the disease is cancer.