Although the clinical picture of the patients described in this publication can resemble that of non-IgE-mediated CMPA, there are significant differences: In the case of allergies, it is impossible to obtain remission of symptoms without the elimination of the allergen, i.e., cow’s milk, and additionally, confirmation of non-IgE-mediated CMPA requires an oral provocation test, in which symptoms reappear after the reintroduction of milk [30]. Here, IGHE is linked to allergic disease.