Cancer cells along with T regulatory cells (Tregs), MDSCs, adipocytes, and tumor-associated macrophages (TAM) can hinder immune control of tumors by producing and releasing cytokines, such as interleukin-10 (IL-10), chemokines, such as chemokine C-X-C motif ligand 12 (CXCL12), growth factors, such as transforming growth factor beta (TGF-β), matrix remodeling factors, such as collagen, fibronectin, and fibrin, and other soluble factors, such as adenosine, into the TME [26,27]. Here, IL10 is linked to cancer.