While the action of histone H4 was hypothesized as a potential inducer of apoptosis, its extensive regulatory effects on CXCL1 and CXCL5, as well as the other tumor suppressors such as LIMA1, DSP, p53, and Trail in osteocyte-derived CM, were unexpected (Figure 7J). The gene discussed is CXCL1; the disease is neoplasm.