MMP2 and cancer: For example, NIR/PET probes sensitive for MMP-2, -9 and -13 were used for detection of tumors in a mouse cancer model [281], a FRET/SPECT probe designed for MMP-2 and was used for in vivo imaging of metastatic lymph nodes [282] and a FRET/MRI probe was developed for MMP-2 and bimodal imaging of gastric tumors [283].