The most important of the rhomboids are RHBDL2 (Rhomboid-related protein 2), which can trigger the activation of the EGF receptor [160] and has been found to be highly expressed in breast cancer [161] and RHBDL4 (Rhomboid-related protein 4), which triggers non-canonical secretion of TGFα [162]. The gene discussed is RHBDD1; the disease is breast cancer.