In CACHD1kn cells, the expression of stress response-associated proteins, such as superoxide dismutase 2 (SOD2), epoxide hydrolase 1 (EPHX1), nucleophosmin (NPM1), Y box binding protein 1 (YBX1), serological liver disease and HCC markers, aspartate aminotransferase 2 (GOT2) and alpha-fetoprotein (AFP), expression was decreased, while the expression of autophagy inducers, nucleolin (NCL) and Lemur tyrosine kinase 3 (LMTK3), was elevated. The gene discussed is EPHX1; the disease is hepatocellular carcinoma.