Moreover, CACHD1 has been recently identified as a substrate of γ-secretase in CNS, which is well-known for its role in Notch signaling and in Alzheimer’s disease, where it catalyzes the formation of the pathogenic amyloid beta (Abeta) peptide [23,24], which modulates voltage-gated Ca2+ channel activity [17,18,19]. The gene discussed is CACHD1; the disease is early-onset autosomal dominant Alzheimer disease.