Therefore, a role of the specific KCNA2 variant p.Tyr417Cys in benign infantile epilepsy (BFIS) appears possible, with a reduced penetrance, similar to other known genetic causes of infantile seizures such as PRRT2 [49], SCN2A [50], and SCN8A [51]. Here, SCN8A is linked to benign familial infantile epilepsy.