Terms like “prion-like” and “prionoid” are commonly used to describe these singular features (including conformational strain-like properties and experimental cell-to-cell spreading of pathogenic protein isoforms) observed, for example, in tauopathies, synucleinopathies, and TDP-43 pathologies, among others [1,2,3]. This evidence concerns the gene TARDBP and synucleinopathy.