Copy number losses were detected in 4/25 (16%) patients for STK11 and in 3/25 (12%) patients for PTEN. Copy number amplifications were detected in 3/25 (12%) patients for PIK3CA. The PI3K pathway is frequently activated in cervical cancer, and the PI3K pathway-related gene PIK3CA was frequently altered in all histological types (Figure 1 and Figure 2A). The gene discussed is PIK3CA; the disease is cervical carcinoma.