A recent prospective study assessed the impact of several angiotensin II-stimulating (thiazides, dihydropyridine calcium channel blockers, AT1R blockers) and angiotensin II-inhibiting (ACE inhibitors, β-blockers, nondihydropyridine calcium channel blockers) antihypertensive drugs on the risk of dementia in older people (70–78 years at baseline) [87]. This evidence concerns the gene ACE and dementia.