The present findings demonstrate dependence of the GPLD1 activity toward micelle-like bAChE complexes (Figure S1) and, less pronouncedly, GPLD1 protein (Figure 1) in serum, as determined by chip-based sensing, on the glycemic and insulinemic state of high-fat diet-fed and genetic rat models of diabetes and obesity with the ranking order obese ZDF > obese ZF > obese Wistar > lean ZDF > lean ZF > lean Wistar. Here, GPLD1 is linked to Obesity.