Additionally, the authors have found that E2F1 directly binds to the DDX11 promoter region by chromatin immunoprecipitation (ChIP) experiments, and in HCC cells, where DDX11 is upregulated, level of the p21 tumor suppressor is reduced, whereas DDX11-knockout restores p21 expression [54,55]. This evidence concerns the gene E2F1 and hepatocellular carcinoma.