Of note, in the same study it was found that DDX11 overexpression could reverse the inhibition of proliferation, migration and invasiveness of U2OS and HOS cells due to DDX11-AS1 loss and, consistently, experiments in xenograft nude mice osteosarcoma model have revealed that DDX11 over-expression could countervail the suppressive role of silenced DDX11-AS1 on tumor growth. The gene discussed is DDX11; the disease is osteosarcoma.