In particular, significantly higher frequencies of VEGF, placental growth factor (PlGF), IL-8, MMP-9, and angiogenin-producing NK cells were present in the tumor (Figure 6B–F), while the frequency of angiopoietin 1 (ANGPT1), osteopontin, and CXCL10 (IP-10)-positive NK cells was similar between the two compartments (Figure 6G–I). This evidence concerns the gene SPP1 and neoplasm.