The composition of HCC-infiltrating NK cells from our study is similar to what was reported for dNK cells; more than 50% are CD27-CD11b- and about 20% are CD27-SP, indicating an association with a high level of NKG2A and peculiar NKp44 upregulation, while NKG2D is downregulated and degranulation (CD107a) capacity is reduced [55,58,68,69]. The gene discussed is CD27; the disease is hepatocellular carcinoma.